NSAIDs (Topical)

11%

Improve with treatment

40%

Improve with control

49%

Do not Improve

What does improve mean?

An example of a 30% reduction in pain scores is a decrease from 6 to 4 on a 10 point pain scale

0
1
2
3
4
5
6
7
8
9
10

How many people will improve?

51%

Improvement by treatment or placebo

49%

No Improvement

NSAIDs (Topical) Harms

Withdrawal due to Adverse Events
5.5%
3.5% (placebo)
Gastrointestinal Adverse Events
3.4%
3.1% (placebo)
Local Site Reactions
15.3%
12.9% (placebo)

Other Considerations

  • Data unavailable to support one formulation or concentration over another.
  • Approximate cost (CAD) for over-the-counter Diclofenac 1.12% , 100g for ~$15

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Osteoarthritis Pain

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